For which adverse effect does the nurse monitor in a patient taking hydroxyzine?

hydroxyzine increases toxicity of amiodarone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

amisulpride and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.

hydroxyzine and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.

artemether and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

artemether/lumefantrine and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.

asenapine transdermal and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

bedaquiline and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

ceritinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

chloroquine and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine increases toxicity of citalopram by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

hydroxyzine increases toxicity of clozapine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

crizotinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

desflurane and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine increases toxicity of droperidol by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

hydroxyzine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.

encorafenib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

entrectinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

eribulin and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

fexinidazole and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.

hydroxyzine and flecainide both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine increases toxicity of fluoxetine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

hydroxyzine and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine increases toxicity of iloperidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

isocarboxazid increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

hydroxyzine and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.

lefamulin and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

hydroxyzine and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and mobocertinib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

hydroxyzine and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and ozanimod both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and pimozide both increase QTc interval. Contraindicated.

hydroxyzine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.hydroxyzine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine increases toxicity of procainamide by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

hydroxyzine and propafenone both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine increases toxicity of quetiapine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

hydroxyzine increases toxicity of quinidine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

hydroxyzine and quinine both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and selpercatinib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and sevoflurane both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and siponimod both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

hydroxyzine and sorafenib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine increases toxicity of sotalol by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

hydroxyzine and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and toremifene both increase QTc interval. Avoid or Use Alternate Drug.

tranylcypromine increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines.

hydroxyzine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.

hydroxyzine increases toxicity of ziprasidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

hydroxyzine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and alfentanil both increase sedation. Use Caution/Monitor.

alfuzosin and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and alprazolam both increase sedation. Use Caution/Monitor.

hydroxyzine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.

hydroxyzine and amitriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and amitriptyline both increase QTc interval. Use Caution/Monitor.

hydroxyzine and amobarbital both increase sedation. Use Caution/Monitor.

hydroxyzine and amoxapine both increase sedation. Use Caution/Monitor.

hydroxyzine and apomorphine both increase sedation. Use Caution/Monitor.apomorphine and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and aripiprazole both increase sedation. Use Caution/Monitor.aripiprazole and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

atomoxetine and hydroxyzine both increase QTc interval. Use Caution/Monitor.

azelastine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine and baclofen both increase sedation. Use Caution/Monitor.

hydroxyzine and belladonna and opium both increase sedation. Use Caution/Monitor.

hydroxyzine and benperidol both increase sedation. Use Caution/Monitor.

hydroxyzine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

brexanolone, hydroxyzine. Either increases toxicity of the other by sedation. Use Caution/Monitor.

brompheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and buprenorphine both increase sedation. Use Caution/Monitor.hydroxyzine and buprenorphine both increase QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, consider consider dose reduction of one or both drugs due to potential for additive pharmacological effects

hydroxyzine and buprenorphine buccal both increase sedation. Use Caution/Monitor.

hydroxyzine and butabarbital both increase sedation. Use Caution/Monitor.

hydroxyzine and butalbital both increase sedation. Use Caution/Monitor.

hydroxyzine and butorphanol both increase sedation. Use Caution/Monitor.

hydroxyzine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

carbinoxamine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and carisoprodol both increase sedation. Use Caution/Monitor.

hydroxyzine and chloral hydrate both increase sedation. Use Caution/Monitor.

hydroxyzine and chlordiazepoxide both increase sedation. Use Caution/Monitor.

chlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and chlorpromazine both increase sedation. Use Caution/Monitor.hydroxyzine increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine and chlorzoxazone both increase sedation. Use Caution/Monitor.

cinnarizine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and ciprofloxacin both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases toxicity of clarithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

clemastine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

hydroxyzine and clomipramine both increase sedation. Use Caution/Monitor.hydroxyzine and clomipramine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and clonazepam both increase sedation. Use Caution/Monitor.

clonidine, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.

hydroxyzine and clorazepate both increase sedation. Use Caution/Monitor.

hydroxyzine and clozapine both increase sedation. Use Caution/Monitor.

hydroxyzine and codeine both increase sedation. Use Caution/Monitor.

cyclizine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and cyclobenzaprine both increase sedation. Use Caution/Monitor.

cyproheptadine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and dantrolene both increase sedation. Use Caution/Monitor.

hydroxyzine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

dasatinib and hydroxyzine both increase QTc interval. Use Caution/Monitor.

degarelix and hydroxyzine both increase QTc interval. Use Caution/Monitor.

desflurane and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and desipramine both increase sedation. Use Caution/Monitor.hydroxyzine and desipramine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and deutetrabenazine both increase sedation. Use Caution/Monitor.deutetrabenazine and hydroxyzine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).

dexchlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and dexmedetomidine both increase sedation. Use Caution/Monitor.

hydroxyzine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and dextromoramide both increase sedation. Use Caution/Monitor.

hydroxyzine and diamorphine both increase sedation. Use Caution/Monitor.

hydroxyzine and diazepam both increase sedation. Use Caution/Monitor.

diazepam intranasal, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.

hydroxyzine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

difelikefalin and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and difenoxin hcl both increase sedation. Use Caution/Monitor.

dimenhydrinate and hydroxyzine both increase sedation. Use Caution/Monitor.

diphenhydramine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

hydroxyzine and dipipanone both increase sedation. Use Caution/Monitor.

hydroxyzine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

dolasetron and hydroxyzine both increase QTc interval. Use Caution/Monitor.

donepezil and hydroxyzine both increase QTc interval. Use Caution/Monitor.

donepezil transdermal, hydroxyzine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.

hydroxyzine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and dosulepin both increase sedation. Use Caution/Monitor.

hydroxyzine and doxepin both increase sedation. Use Caution/Monitor.doxepin and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and doxylamine both increase sedation. Use Caution/Monitor.

hydroxyzine and droperidol both increase sedation. Use Caution/Monitor.

efavirenz and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and eliglustat both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine increases toxicity of erythromycin base by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine increases toxicity of erythromycin ethylsuccinate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine increases toxicity of erythromycin lactobionate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine increases toxicity of erythromycin stearate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine and escitalopram both increase QTc interval. Use Caution/Monitor.

esketamine intranasal, hydroxyzine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

hydroxyzine and estazolam both increase sedation. Use Caution/Monitor.

hydroxyzine and ethanol both increase sedation. Use Caution/Monitor.

etomidate and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and ezogabine both increase QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed, particularly when dose titrated to 1200mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.

hydroxyzine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

fentanyl, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

fentanyl intranasal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

fentanyl transdermal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

fentanyl transmucosal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

fingolimod and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.

hydroxyzine and fluconazole both increase QTc interval. Use Caution/Monitor.

hydroxyzine and fluphenazine both increase sedation. Use Caution/Monitor.hydroxyzine and fluphenazine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and flurazepam both increase sedation. Use Caution/Monitor.

hydroxyzine and fluvoxamine both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.

gabapentin, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

gabapentin enacarbil, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

hydroxyzine and ganaxolone both increase sedation. Use Caution/Monitor.

gemifloxacin and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and gemtuzumab both increase QTc interval. Use Caution/Monitor.

gilteritinib and hydroxyzine both increase QTc interval. Use Caution/Monitor.

glycopyrronium tosylate topical, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.

hydroxyzine and goserelin both increase QTc interval. Use Caution/Monitor.

gotu kola increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

granisetron and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and haloperidol both increase sedation. Use Caution/Monitor.hydroxyzine and haloperidol both increase QTc interval. Use Caution/Monitor.

hawthorn increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

hydroxyzine and histrelin both increase QTc interval. Use Caution/Monitor.

hops increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

hydroxyzine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.

hydroxyzine and hydromorphone both increase sedation. Use Caution/Monitor.

hydroxyzine and iloperidone both increase sedation. Use Caution/Monitor.

hydroxyzine and imipramine both increase sedation. Use Caution/Monitor.hydroxyzine and imipramine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and inotuzumab both increase QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, obtain baseline ECG to assess initial QT interval and determine frequency of subsequent monitoring; avoid non-essential QT prolonging drug and correct electrolyte imbalances

hydroxyzine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and itraconazole both increase QTc interval. Use Caution/Monitor.itraconazole and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and ivosidenib both decrease QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, obtain baseline ECG to assess initial QT interval and determine frequency of subsequent monitoring; avoid non-essential QT prolonging drug and correct electrolyte imbalances

kava increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

ketamine and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

hydroxyzine and lapatinib both increase QTc interval. Use Caution/Monitor.

lasmiditan, hydroxyzine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

lemborexant, hydroxyzine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

hydroxyzine and leuprolide both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and levofloxacin both increase QTc interval. Use Caution/Monitor.

hydroxyzine and levorphanol both increase sedation. Use Caution/Monitor.

hydroxyzine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and lithium both increase QTc interval. Use Caution/Monitor.

hydroxyzine and lofepramine both increase sedation. Use Caution/Monitor.

hydroxyzine and lofexidine both increase sedation. Use Caution/Monitor.

hydroxyzine and loperamide both increase QTc interval. Use Caution/Monitor.

hydroxyzine and loprazolam both increase sedation. Use Caution/Monitor.

hydroxyzine and lorazepam both increase sedation. Use Caution/Monitor.

hydroxyzine and lormetazepam both increase sedation. Use Caution/Monitor.

hydroxyzine and loxapine both increase sedation. Use Caution/Monitor.

hydroxyzine and loxapine inhaled both increase sedation. Use Caution/Monitor.

lurasidone, hydroxyzine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

hydroxyzine and maprotiline both increase sedation. Use Caution/Monitor.hydroxyzine and maprotiline both increase QTc interval. Use Caution/Monitor.

hydroxyzine and marijuana both increase sedation. Use Caution/Monitor.

hydroxyzine and mefloquine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and melatonin both increase sedation. Use Caution/Monitor.

hydroxyzine and meperidine both increase sedation. Use Caution/Monitor.

hydroxyzine and meprobamate both increase sedation. Use Caution/Monitor.

hydroxyzine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and metaxalone both increase sedation. Use Caution/Monitor.

hydroxyzine and methadone both increase sedation. Use Caution/Monitor.hydroxyzine increases toxicity of methadone by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and methocarbamol both increase sedation. Use Caution/Monitor.

hydroxyzine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and midazolam both increase sedation. Use Caution/Monitor.

midazolam intranasal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

hydroxyzine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and mirtazapine both increase sedation. Use Caution/Monitor.hydroxyzine and mirtazapine both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and morphine both increase sedation. Use Caution/Monitor.

hydroxyzine and motherwort both increase sedation. Use Caution/Monitor.

hydroxyzine increases toxicity of moxifloxacin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine and moxonidine both increase sedation. Use Caution/Monitor.

hydroxyzine and nabilone both increase sedation. Use Caution/Monitor.

hydroxyzine and nalbuphine both increase sedation. Use Caution/Monitor.

hydroxyzine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and nortriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and nortriptyline both increase QTc interval. Use Caution/Monitor.

hydroxyzine and octreotide both increase QTc interval. Use Caution/Monitor.

hydroxyzine and ofloxacin both increase QTc interval. Use Caution/Monitor.

hydroxyzine and olanzapine both increase sedation. Use Caution/Monitor.hydroxyzine and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances

hydroxyzine increases toxicity of ondansetron by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine and opium tincture both increase sedation. Use Caution/Monitor.

hydroxyzine and orphenadrine both increase sedation. Use Caution/Monitor.

osilodrostat and hydroxyzine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and oxazepam both increase sedation. Use Caution/Monitor.

hydroxyzine and oxycodone both increase sedation. Use Caution/Monitor.

hydroxyzine and oxymorphone both increase sedation. Use Caution/Monitor.

hydroxyzine and paliperidone both increase sedation. Use Caution/Monitor.

hydroxyzine and papaveretum both increase sedation. Use Caution/Monitor.

hydroxyzine and papaverine both increase sedation. Use Caution/Monitor.

hydroxyzine and paroxetine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and pasireotide both increase QTc interval. Use Caution/Monitor.

passion flower increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

hydroxyzine increases toxicity of pentamidine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

hydroxyzine and pentazocine both increase sedation. Use Caution/Monitor.

hydroxyzine and pentobarbital both increase sedation. Use Caution/Monitor.

perampanel and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and perphenazine both increase sedation. Use Caution/Monitor.hydroxyzine and perphenazine both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

phenelzine increases effects of hydroxyzine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

hydroxyzine and phenobarbital both increase sedation. Use Caution/Monitor.

hydroxyzine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

hydroxyzine and pholcodine both increase sedation. Use Caution/Monitor.

hydroxyzine and pimozide both increase sedation. Use Caution/Monitor.

hydroxyzine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and posaconazole both increase QTc interval. Use Caution/Monitor.

pregabalin, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

hydroxyzine and primaquine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and primidone both increase sedation. Use Caution/Monitor.

hydroxyzine and prochlorperazine both increase sedation. Use Caution/Monitor.hydroxyzine and prochlorperazine both decrease QTc interval. Use Caution/Monitor.

hydroxyzine and promethazine both increase sedation. Use Caution/Monitor.hydroxyzine and promethazine both decrease QTc interval. Use Caution/Monitor.

propofol and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and protriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and protriptyline both increase QTc interval. Use Caution/Monitor.

hydroxyzine and quazepam both increase sedation. Use Caution/Monitor.

hydroxyzine and quetiapine both increase sedation. Use Caution/Monitor.

hydroxyzine and ramelteon both increase sedation. Use Caution/Monitor.

hydroxyzine and ranolazine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and rilpivirine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and risperidone both increase sedation. Use Caution/Monitor.hydroxyzine and risperidone both increase QTc interval. Use Caution/Monitor.

hydroxyzine and romidepsin both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and scullcap both increase sedation. Use Caution/Monitor.

hydroxyzine and secobarbital both increase sedation. Use Caution/Monitor.

hydroxyzine and sertraline both increase QTc interval. Use Caution/Monitor.

sevoflurane and hydroxyzine both increase sedation. Use Caution/Monitor.

hydroxyzine and shepherd's purse both increase sedation. Use Caution/Monitor.

hydroxyzine and solifenacin both increase QTc interval. Use Caution/Monitor.

stiripentol, hydroxyzine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

hydroxyzine and sufentanil both increase sedation. Use Caution/Monitor.

hydroxyzine and sunitinib both increase QTc interval. Use Caution/Monitor.

hydroxyzine and tacrolimus both increase QTc interval. Use Caution/Monitor.

hydroxyzine and tapentadol both increase sedation. Use Caution/Monitor.

hydroxyzine and telavancin both increase QTc interval. Use Caution/Monitor.

hydroxyzine and temazepam both increase sedation. Use Caution/Monitor.

hydroxyzine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and thioridazine both increase sedation. Use Caution/Monitor.

hydroxyzine and thiothixene both increase sedation. Use Caution/Monitor.

hydroxyzine and topiramate both increase sedation. Modify Therapy/Monitor Closely.

hydroxyzine and tramadol both increase sedation. Use Caution/Monitor.

hydroxyzine and trazodone both increase sedation. Use Caution/Monitor.

hydroxyzine and triazolam both increase sedation. Use Caution/Monitor.

hydroxyzine and triclabendazole both increase QTc interval. Use Caution/Monitor.

hydroxyzine and triclofos both increase sedation. Use Caution/Monitor.

hydroxyzine and trifluoperazine both increase sedation. Use Caution/Monitor.hydroxyzine and trifluoperazine both decrease QTc interval. Use Caution/Monitor.

hydroxyzine and trimipramine both increase sedation. Use Caution/Monitor.hydroxyzine and trimipramine both increase QTc interval. Use Caution/Monitor.

hydroxyzine and triprolidine both increase sedation. Use Caution/Monitor.

hydroxyzine and triptorelin both increase QTc interval. Use Caution/Monitor.

valbenazine and hydroxyzine both increase QTc interval. Use Caution/Monitor.

valerian increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

hydroxyzine and vardenafil both increase QTc interval. Use Caution/Monitor.

hydroxyzine and venlafaxine both decrease QTc interval. Use Caution/Monitor.

hydroxyzine and voclosporin both increase QTc interval. Use Caution/Monitor.

hydroxyzine and vorinostat both increase QTc interval. Use Caution/Monitor.

hydroxyzine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

hydroxyzine and ziconotide both increase sedation. Use Caution/Monitor.

hydroxyzine and ziprasidone both increase sedation. Use Caution/Monitor.

hydroxyzine and zotepine both increase sedation. Use Caution/Monitor.