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What is Graves’ disease?Graves’ disease is an autoimmune disorder that can cause hyperthyroidism, or overactive thyroid. The thyroid is a small, butterfly-shaped gland in the front of your neck. Thyroid hormones control the way your body uses energy, so they affect nearly every organ in your body, even the way your heart beats. With Graves’ disease, your immune system attacks your thyroid gland, causing it to make more thyroid hormones than your body needs. As a result, many of your body’s functions speed up. How common is Graves’ disease?Graves’ disease affects nearly 1 in 100 Americans.1 About 4 out of 5 cases of hyperthyroidism in the United States are caused by Graves’ disease.1 Who is more likely to have Graves’ disease?Graves’ disease is more common in women and people older than age 30.2 You are more likely to develop the disease if you
What are the complications of Graves’ disease?Untreated, Graves’ disease can cause serious health problems, including
What are the symptoms of Graves’ disease?Graves’ disease often causes symptoms of hyperthyroidism. Graves’ disease can also affect your eyes and skin. Symptoms can come and go over time. HyperthyroidismSymptoms of hyperthyroidism can vary from person to person and may include5
Eye problemsMore than 1 in 3 people with Graves’ disease develop an eye disease called Graves’ ophthalmopathy (GO).6 GO occurs when your immune system attacks the muscles and other tissues around your eyes. Symptoms can include
These symptoms can start before or at the same time as symptoms of hyperthyroidism. Rarely, GO can develop after Graves’ disease has been treated. You can develop GO even if your thyroid function is normal. Most people have mild symptoms. Skin problemsRarely, people with Graves’ disease develop a condition that causes the skin to become reddish and thick, with a rough texture. Called Graves’ dermopathy or pretibial myxedema, the condition usually affects your shins but can also develop on the top of your feet and other parts of your body. Most cases are mild and painless. What causes Graves’ disease?Researchers aren’t sure why some people develop autoimmune disorders such as Graves’ disease. These disorders probably develop from a combination of genes and an outside trigger, such as a virus. With Graves’ disease, your immune system makes an antibody called thyroid-stimulating immunoglobulin (TSI) that attaches to your thyroid cells. TSI acts like thyroid-stimulating hormone (TSH), a hormone made in your pituitary gland that tells your thyroid how much thyroid hormone to make. TSI causes your thyroid to make too much thyroid hormone. How do doctors diagnose Graves’ disease?Your doctor will take your medical history and perform a physical exam to look for signs of Graves’ disease. To confirm a diagnosis of Graves’ disease, your doctor may order one or more of these thyroid tests
How do doctors treat Graves’ disease?Treating hyperthyroidismHyperthyroidism is usually treated with medicines, radioiodine therapy, or thyroid surgery. Your doctor can help you identify the best option based on your age, health, symptoms, and other factors. MedicinesBeta-blockers. Beta-blockers are drugs that block the action of substances, such as adrenaline, on nerve cells. They cause blood vessels to relax and widen.
Antithyroid medicines. Antithyroid therapy is the simplest way to treat hyperthyroidism. Methimazole is used most often. Propylthiouracil is often used for women during the first 3 months of pregnancy because methimazole can, on rare occasions, harm the fetus.
Seek care right away While taking antithyroid drugs, call your doctor right away if you have any of the following symptoms
Radioiodine therapyRadioiodine therapy is a common and effective treatment. You can take radioactive iodine-131 by mouth as a capsule or liquid.
Almost everyone who gets radioiodine therapy later develops hypothyroidism. But hypothyroidism is easier to treat than hyperthyroidism by taking a daily thyroid hormone medicine, and it causes fewer long-term health problems.
Thyroid surgerySurgery to remove part or most of the thyroid gland is used less often to treat hyperthyroidism. Sometimes doctors use surgery to treat people with large goiters or pregnant women who cannot take antithyroid medicines.
When part of your thyroid is removed, you may develop hypothyroidism after surgery and need to take thyroid hormone medicine. If your whole thyroid is removed, you will need to take thyroid hormone medicine for life. After surgery, your doctor will continue to check your thyroid hormone levels and will adjust your thyroid medicine dosage as needed.
Treating GOMost cases of GO are mild. The following tips may help you control mild symptoms.
GO often improves with treatment or even resolves on its own. But it can come back or get worse. Triggers include stressful life events and smoking.6 Smoking makes GO worse. If you smoke or use other tobacco products, stop. Ask for help so you don’t have to do it alone. You can start by calling the National Quitline at 1-800-QUITNOW or 1-800-784-8669. For tips on quitting, go to Smokefree.gov. How do eating, diet, and nutrition affect Graves’ disease?Your thyroid uses iodine to make thyroid hormones. If you have Graves’ disease or another autoimmune thyroid disorder, you may be sensitive to harmful side effects from too much iodine in your diet. Eating foods that have large amounts of iodine—such as kelp, dulse, or other kinds of seaweed—may cause or worsen hyperthyroidism. Taking iodine supplements can have the same effect. Talk with your health care professional about
Clinical Trials for Graves’ DiseaseThe NIDDK conducts and supports clinical trials in many diseases and conditions, including endocrine diseases. The trials look to find new ways to prevent, detect, or treat disease and improve quality of life. What are clinical trials for Graves’ disease?Clinical trials—and other types of clinical studies—are part of medical research and involve people like you. When you volunteer to take part in a clinical study, you help doctors and researchers learn more about disease and improve health care for people in the future. Researchers are studying many aspects of Graves’ disease, including new medicines for treating Graves’ disease and GO. Watch a video of NIDDK Director Dr. Griffin P. Rodgers explaining the importance of participating in clinical trials.
What clinical studies for Graves’ disease are looking for participants?You can view a filtered list of clinical studies on Graves’ disease that are open and recruiting at www.ClinicalTrials.gov. You can expand or narrow the list to include clinical studies from industry, universities, and individuals; however, the National Institutes of Health does not review these studies and cannot ensure they are safe. Always talk with your health care provider before you participate in a clinical study. ReferencesLast Reviewed November 2021 This content is provided as a service of the National Institute of Diabetes and
Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts. The NIDDK would like to thank: Which condition is an autoimmune disorder in which the immune system mistakenly attacks thyroid?Graves' disease is an autoimmune disorder that can cause hyperthyroidism, or overactive thyroid. The thyroid is a small, butterfly-shaped gland in the front of your neck.
What autoimmune disease causes thyroid problems?Hashimoto's disease is an autoimmune disorder that can cause hypothyroidism, or underactive thyroid. Rarely, the disease can cause hyperthyroidism, or overactive thyroid. Thyroid hormones control how your body uses energy, so they affect nearly every organ in your body—even the way your heart beats.
What is the most common autoimmune disease of the thyroid gland?Abstract. Autoimmune diseases of the thyroid gland are considered to be the most frequent cause of thyroid gland disorders. Autoimmune thyroid diseases consist of two subgroups: autoimmune thyroiditis (AIT) and Graves' disease. The AIT is the most common human autoimmune disease.
What is thyroid autoimmunity?An autoimmune thyroid disease (AITD) occurs when the body's immune system mistakenly attacks or overstimulates the thyroid gland.
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