Complications - Indwelling CathetersOverview | Bacteriuria | CAUTIs | Catheter-Associated Biofilms Show Catheter-Associated Complications Catheter related problems due to an indwelling urinary catheter (IUC) have existed as long as urinary catheters have been utilized. This section will review IUC complications: infectious complications such as (symptomatic bacterial infection, cystitis, pyelonephritis, urosepsis, and epididymitis), catheter blockage (due to calculi, biofilms, and encrustations), catheter related malignancy, hematuria, stones, urethral stricture and fistula from urethral injury, traumatic hypospadias, and periurethral urine leakage. Catheter-associated UTIs (CAUTIs) One of the most common and severe complication that occurs with urinary catheters is a UTI, referred to as a “catheter-associated urinary tract infection” or CAUTI. A CAUTI can lead to urosepsis and septicemia, Infections are common because urethral catheters inoculate organisms into the bladder and promote colonization by providing a surface for bacterial adhesion and causing mucosal irritation. The presence of a urinary catheter is the most important risk factor for bacteriuria. Most bacteria causing CAUTI gain access to the urinary tract either extraluminally or intraluminally.Extraluminal contamination may occur as the catheter is inserted, by contamination of the catheter from any source. Extraluminal contamination is thought to also occurby microorganisms ascending from the perineum along the surface of the catheter. Most episodes of bacteriuria in catheterized women are believed to occur through the extraluminal entry of organisms. Fecal strains contaminate the perineum and urethral meatus, and then ascend to the bladder along the external surface to cause bacteriuria, catheter biofilm formation, and encrustation. Intraluminal contamination occurs by ascent of bacteria from a contaminated catheter, drainage tube, or urine drainage bag. Microorganisms can migrate up the catheter into the bladder within 1 to 3 days. At least 66% of CAUTIs result from extraluminal contamination, whereas 34% are a result of the intraluminal route. There are three catheter-associated entry points for bacteria:
All 3 of these mechanisms involved in the pathogenesis of colonization and infection of the urinary tract combine to make CAUTI very difficult to prevent in individuals with urinary catheters in place for longer than 2 weeks. Bacteriuria Bacteriuria (bacteria in the urine) usually occurs in most patients who have a catheter in place for 2 to 10 days. A large number and a variety of types of organisms are present in the periurethral area and in the distal part of the urethra that may be introduced into the bladder at the time of catheter insertion. Other factors that increase the risk of bacteriuria include the presence of residual urine because of inadequate bladder drainage in the bladder (urine stasis promotes bacterial growth), ischemic damage to the bladder mucosa through overdistention, mechanical irritation from the presence of a catheter, and biofilm formation on the catheter intraluminal surface. Once a catheter is placed, the daily incidence of bacteriuria is 3 to 10%. Between 10% and 30% of patients who undergo short-term catheterization (i.e., 2 to 4 days) develop bacteriuria and are asymptomatic. Between 90% and 100% of patients who undergo long-term catheterization develop bacteriuria. About 80% of nosocomial UTIs are related to urethral catheterization; only 5 to 10% are related to genitourinary manipulation. The presence of potentially pathogenic bacteria and an indwelling catheter predisposes to the development of a nosocomial UTI. The bacteria may gain entry into the bladder during insertion of the catheter, during manipulation of the catheter or drainage system, around the catheter, and after removal. Two catheter hygiene principles should be used to prevent bacteriuria:
A systematic review suggested that sealed (e.g., taped, presealed) drainage systems contribute to preventing bacteriuria. The basic components of a closed system include the catheter, a preconnected collecting tube with a needleless aspiration port for obtaining a urine specimen, and a vented drainage bag with a port for drainage. Catheter-associated bacteriuria is usually asymptomatic and uncomplicated, and is left untreated as it gradually resolves in an otherwise normal urinary tract after the catheter is removed. Catheter-Associated Urinary Tract Infections A CAUTI is the most common nosocomial infection in hospitals and nursing homes, comprising more than 40% of all institutionally acquired infections. CAUTIs are considered complicated UTIs and are the most common complication associated with long-term catheter use. CAUTIs may occur at least twice a year in patients with long-term indwelling catheters, requiring hospitalization. They are associated with increased urosepsis, septicemia, and mortality. Catheters are a good medium for bacterial growth because bacterial biofilms (layers of organisms) adhere to the many surfaces of the catheter system. Most CAUTIs involve multiple organisms and resistant bacteria from catheter-associated biofilms (discussed later). These include Enterobacteriaceae other than E. coli (e.g., Klebsiella, Enterobacter, Proteus, and Citrobacter), pseudomonas aeruginosa, enterococci and staphylococci, and Candida. Candiduria is especially common in individuals with prolonged urinary catheterization receiving broad-spectrum, systemic antimicrobial agents. A CAUTI is more likely to occur in women than men; because of the shorter female urethra and because of the urethra’s close proximity to the anus, bacteria have a shorter distance to travel. Due to increased antibiotic use, there has been an increase in antibiotic-resistant microorganisms, particularly P. aeruginosa and C. albicans, two organisms frequently involved in device-associated nosocomial infections. A problem in hospitals and LTC facilities is infection with vancomycin-resistant Enterococcus (VRE) and methicillin resistant staphylococcus aureus (MRSA). In patients with long-term indwelling urinary catheters, symptoms of catheter-related infection are often nonspecific. Symptoms of a UTI are caused by an inflammatory response of the epithelium of the urinary tract to invasion and colonization by bacteria. Among catheterized individuals, clinical manifestations of UTI (pain, urgency, dysuria, fever, and leukocytosis) are uncommon even when bacteria or yeast is present, and are no more prevalent with positive urine culture results than with negative results. Confusion or unexplained fever may be the only symptoms of catheter-related CAUTI in patients residing in nursing homes. Diagnosing catheter-related infection in patients with spinal cord injury (SCI) may be especially challenging from history and physical examination because of a frequent lack of localizing symptoms. Often, the only symptom of catheter-related UTI in individuals with SCI is fever, diaphoresis, abdominal discomfort, or increased muscle spasticity. Catheter-Associated Biofilms Once an indwelling urinary catheter is inserted, bacteria quickly develop into colonies known as biofilms (living layers) that adhere to the catheter surface and drainage bag. A biofilm is a collection of microorganisms with altered phenotypes that colonize the surface of a medical device such as an indwelling urinary catheter. Urine contains protein that adheres to and primes the catheter surface. Microorganisms bind to this protein layer and thus attach to the surface. Such bacteria are different from free-living planktonic bacteria (bacteria that float in urine). Urinary catheter biofilms may initially be composed of single organisms, but longer exposures inevitably lead to multi-organism biofilms. Bacteria in biofilms have considerable survival advantages over free-living microorganisms, being extremely resistant to antibiotic therapy. The link between biofilm and infection is that the biofilm provides a sustained reservoir for microorganisms that, after detachment, can infect the patient. These biofilms cause further problems if the bacteria (e.g., P. mirabilis) produce the enzyme urease.The urine then becomes alkaline (increased pH), causing the production of ammonium ions, followed by crystallization of calcium and magnesium phosphate within the urine. These crystals are then incorporated into the biofilm, resulting in encrustation of the catheter over a period of time. Several features of biofilms have important implications for the development of antimicrobial resistance in organisms growing within the biofilm. Because the presence of the biofilm inhibits antimicrobial activity, organisms within the biofilm cannot be eradicated by antimicrobial therapy alone. The urinary biofilm provides a protective environment for the microorganisms, which allows evasion of the activity of antimicrobial agents. The biofilm also allows for microbial attachment to catheter surfaces in a manner that does not allow for removal with gentle rinsing, such as irrigation. Biofilms can begin to develop within the first 24 hours after catheter insertion. Biofilms have reportedly become so thick in some circumstances as to block a catheter lumen. The presence of urinary catheter biofilms has important implications for antimicrobial resistance, diagnosis of UTIs, and the prevention and treatment of CAUTIs. Encrustations Mineral deposition within the catheter biofilm causes encrustations, which are unique to biofilms formed on urinary catheters. Encrustations are seen typically on the inner surface of the catheter and can build to block catheter flow completely. They can coat the balloon, making it hard to deflate. Once the balloon is deflated, they fall off into the bladder. Encrustations are generally associated with long-term catheterization, because it has a direct relationship with the duration of catheterization. Some patients are more prone to persistent catheter encrustation, and these patients are referred to as “blockers” as opposed to “nonblockers.” As noted previously, an alkaline urinary pH is an important factor in causing catheter encrustation. Urosepsis Urosepsis can result from a UTI, leading to generalized sepsis, and death from severe UTIs has been reported. Mortality has been documented as more than 3 times higher in catheterized than in noncatheterized individuals. Urethral Damage Urethral damage occurs primarily in men because the catheter may interfere with drainage of seminal secretions. Urethral catheterization in men is associated with epididymitis, orchitis, scrotal abscess, prostatitis, and prostatic abscess. It can start at the time of insertion of the catheter but increases with long-term catheter use. Difficulty passing the catheter may mean that the catheter has encountered a urethral stricture, has entered or created a false passage in the urethra, or that its passage is blocked by an obstructing prostate, bladder neck, or sphincter. The catheter may turn on itself and curl in the urethra. The following are common urethral complications:
Other complications associated with indwelling catheter use include the following:
References: 1.
Alexaitis I, Broome B. Implementation of a nurse-driven protocol to prevent catheter-associated urinary tract infections. J Nurs Care Qual. 2014;29:245-52. DOI: 10.1097/NCQ.0000000000000041 Which action will help prevent accidental dislodgement of an indwelling urinary catheter quizlet?C. It is important to anchor the catheter tubing to minimize the risk for urethral trauma, bladder spasms from traction, and to prevent accidental dislodgment.
Where should an indwelling urinary catheter be secured for a female patient?Secure the catheter to your patient's thigh with enough slack to prevent movement from creating tension on the catheter. Secure the drainage bag on the bed frame below her bladder level. Provide perineal care, then remove your gloves and wash your hands.
What holds an indwelling catheter in place?intermittent catheters – these are temporarily inserted into the bladder and removed once the bladder is empty. indwelling catheters – these remain in place for many days or weeks, and are held in position by an inflated balloon in the bladder.
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