Twin concordance for DSM-III-R schizophreniaS Onstad et al. Acta Psychiatr Scand. 1991 May. Show
AbstractThe monozygotic (MZ)/dizygotic (DZ) concordance rates for schizophrenia and the relationship between schizophrenia and schizophrenic spectrum disorders were studied in a sample of 31 MZ and 28 DZ schizophrenic probands and their co-twins. All subjects were personally interviewed with structured diagnostic instruments and classified according to DSM-III-R criteria. The concordance rates of 48% for MZ twins and 4% for DZ twins indicate a genetic transmission of DSM-III-R schizophrenia. In addition to the schizophrenic co-twins, 3 MZ co-twins had a noneffective psychotic disorder, thus supporting the hypothesis that genes are involved in the development of Axis I schizophrenic spectrum disorders. Schizotypal and paranoid personality disorders were observed in both MZ and DZ co-twins. These disorders may be familially related to schizophrenia, but a genetic relationship was not confirmed for the Axis II spectrum disorders. A substantial number of MZ co-twins of schizophrenic probands had no mental disorder. Similar articles
Cited by
Publication typesMeSH termsLinkOut - more resources
What is the concordance rate for schizophrenia in monozygotic MZ twins?The concordance rates of 48% for MZ twins and 4% for DZ twins indicate a genetic transmission of DSM-III-R schizophrenia.
What is the concordance rate in monozygotic twins?Monozygotic and dizygotic twin concordances are approximately 85% and 50%, respectively, for reading, and 70% and 50% for mathematics.
What is the rate of schizophrenia in identical twins quizlet?Identical twins more likely to develop schizophrenia than non-identical. They found that when comparing identical twin studies, they had a concordance rate of 40% while non-identical twins had 7.4%.
Are monozygotic twins concordant?Studies of twins have shown that genetic traits of monozygotic twins are fully concordant, whereas in dizygotic twins, half of genetic traits are concordant, while the other half are discordant.
|