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Under a Creative Commons license Open access AbstractTrauma-induced coagulopathy (TIC) is a clinical syndrome caused by imbalance between clotting, anti-coagulation and fibrinolysis resulting from multiple pathological factors such as hemorrhage and tissue injury in the early stage of trauma, and is closely related to the outcome of trauma patients. It is proved in growing evidence that the endogenous coagulation disturbance in trauma itself is the activating factor of TIC, rather than dilution or other acquired coagulopathy. Therefore, a thorough understanding of the molecular mechanisms in the pathogenesis and progression is crucial for effective prevention and treatment in patients with TIC. This review focuses on transitions in the concept of TIC and mechanical progress. KeywordsBlood coagulation disorders Shock Physiopathology Trauma induced coagulopathy Cited by (0)© 2017 Production and hosting by Elsevier B.V. on behalf of Daping Hospital and the Research Institute of Surgery of the Third Military Medical University. A TBI affects how the brain worksA traumatic brain injury, or TBI, is an injury that affects how the brain works. It may be caused by a:
There are three main types of TBI:
TBI is a major cause of death and disability1There were over 64,000 TBI-related deaths in the United States in 2020.3 That’s about 176 TBI-related deaths every day. TBIs affect the lives of people of all ages. Anyone can experience a TBI, but data suggest that some groups are at greater risk of dying from a TBI or experiencing long-term health problems after the injury.4 Examples of groups who are more likely to be affected by TBI, include:
Learn more about health disparities and TBI. People most commonly get TBIs from a fall, firearm-related injury, motor vehicle crash, or an assaultResearch shows that:
For more detailed information on the leading ways people get TBIs and the groups of people most likely to get a TBI, check out CDC’s TBI data reports. A TBI may lead to short- or long-term health problemsDepending on the severity of the injury, those who get a TBI may face health problems that last a few days or the rest of their lives. For example, a person with a mild TBI or concussion may experience short-term symptoms and feel better within a couple of weeks or months. And a person with a moderate or severe TBI may have long-term or life-long effects from the injury. A person with a possible TBI should be seen by a healthcare provider. Your healthcare provider may have treatment to help speed your recovery.
A TBI during childhood may affect brain developmentTBI affects children differently than adults. An injury of any severity to the developing brain may:
As a result of a TBI, children may experience changes in their health, thinking, and behavior that affect learning, self-regulation, and social participation, all of which are important to becoming a productive adult.13 CDC’s Report to Congress on the management of traumatic brain injury in children details the potential effects of a TBI on children and their families.13 TBIs may be missed in older adultsOlder adults are more likely to be hospitalized and die from a TBI compared to all other age groups.11 Still, TBIs may be missed or misdiagnosed in older adults because symptoms of TBI overlap with other medical conditions that are common among older adults, such as dementia. Healthcare providers should check for signs and symptoms of TBI if an older adult has:
This is especially important among older adults who are taking blood thinners,14 such as:
These medicines may increase the risk for bleeding in the brain following a TBI.14 Bleeding in the brain after a TBI may put a person at risk for more severe injury or death. What is the most common cause of death in trauma patients?Traumatic Brain Injury (TBI) is the single largest cause of death from injury in the United States: 1,000,000 people with TBI per year in US: 230,00 hospitalized. 50,000 die (one third of all trauma deaths)
What are the 3 mechanisms of injury?Although there are several different mechanisms of injury, trauma can be categorized broadly into three groups: penetrating, blunt, and deceleration trauma. There is a significant overlap in the causes, outcomes, and body's response to the different injury types.
What is the most common mechanism of injury?Motor vehicle collisions are the leading cause of trauma death in all age groups between 1 to 65 years.
Which of the following injuries would most likely occur as a direct result of the third?Which of the following injuries would MOST likely occur as a direct result of the third collision in a motor vehicle crash? Aortic rupture. Force acting over a distance is the definition of: Work.
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